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Year : 2013  |  Volume : 106  |  Issue : 4  |  Page : 245-248

Evaluation of the role of apelin in diabetic retinopathy

1 Department of Ophthalmology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2 Department of Physiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3 Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Correspondence Address:
Waleed Mahdy Nada
MD, 167 St. Saleh Elsalhy, El Knayat, El Sharkia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2090-0686.131587

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Purpose The study was designed to evaluate the role of apelin in diabetic retinopathy by measuring the concentration of plasma apelin and correlating the results between the control group, diabetic patients without and with retinopathy, and diabetic patients after treatment with panretinal photocoagulation (PRP). Methods The study included four groups: group A consisted of 20 normal individuals as the control group, group B consisted of 20 diabetic patients without retinopathy, group C consisted of 20 diabetic patients with untreated proliferative diabetic retinopathy (PDR), and group D consisted of the same patients of group C after treatment with PRP. Plasma apelin was measured in all groups and interpretation of the results was carried out. Results The study revealed that plasma apelin increased significantly in diabetic patients with PDR (mean 1.6 ng/ml) compared with the control group (mean 0.98 ng/ml) and with diabetic patients without retinopathy (mean 0.97 ng/ml). Plasma apelin decreased nonsignificantly in diabetic patient with PDR after treatment with PRP (mean 1.2 ng/ml). Conclusion Apelin plays an important role in retinal angiogenesis in diabetic patients; measurement of plasma apelin may be a good indicator for ischemic retinal condition, especially in the absence of other ischemic manifestations in the body.

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