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Year : 2013  |  Volume : 106  |  Issue : 3  |  Page : 168-171

Possible changes in intraocular pressure measurements after corneal collagen cross-linking with riboflavin and ultraviolet A in eyes with keratoconus

1 Department of Ophthalmology, Lecturer of Ophthalmology, Cairo University Hospital, Cairo, Egypt
2 Researcher of Ophthalmology, Research Institute of Ophthalmology (RIO), Giza, Egypt

Correspondence Address:
Iman M Eissa
6 Othman-Diplomats-Towers, Othman Buildings, Korniche Al Maadi, Floor 6, Appt. 62, Maadi 11431, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2090-0686.127378

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Purpose The aim of the study was to determine the possible effect of corneal collagen cross-linking (CXL) with riboflavin and ultraviolet A on intraocular pressure (IOP) measurements using Goldmann applanation tonometry (GAT) in eyes with keratoconus. Design The study was designed as a prospective case series and conducted in Al Haram Eye Center and RCC Hospital, Giza, Egypt. Materials and methods This noncomparative study measured IOP using GAT before CXL and at 3, 6, and 12 months after CXL. Results The study evaluated 49 eyes (40 patients). There was a statistically significant increase in the measured IOP at 3, 6, and 12 months after CXL (P<0.001). The mean preoperative IOP was 11.2 mmHg (1.29 SD), whereas the mean postoperative IOP was 12.24 mmHg (1.13 SD) at 3 months, 12.37 mmHg (1.13 SD) at 6 months, and 12.55 mmHg (1.12 SD) at 12 months. We also found a direct correlation between preoperative central corneal thickness and IOP measurements at postoperative examinations. However, postoperative IOP measurements were not correlated with patient age, sex, or preoperative keratometric readings. Conclusion After riboflavin-ultraviolet A CXL in eyes with keratoconus, there was a significant increase in IOP measured using GAT, which was probably caused by an increase in corneal rigidity and not a true increase.

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